Hi @Hexados,
I have fixed the broken link. Thanks for pointing that out.
From your description, the S7-PLCSIM process (Siemens.Simatic.PlcSim.VplcHost) is running, but Factory I/O fails to find it. This may be caused by incorrect Windows account permissions or third-party software, such as an antivirus, that is blocking Factory I/O from accessing the system processes.
Nonetheless, I would like to look at the Factory I/O log file. Can you try to connect to S7-PLCSIM again using the S7-PLCSIM driver and send us the log file to support [at] realgames.pt? Don’t post it since it may contain sensitive information. See how to get the log file here.